Get Antiangiogenic Agents in Cancer Therapy, Second Edition PDF

By Beverly A. Teicher

ISBN-10: 1588298701

ISBN-13: 9781588298706

Antiangiogenesis continues to be a dynamic and evolving box in oncology. New healing pursuits proceed to emerge through the speedy improvement of recent healing brokers to be investigated in medical trials. Optimizing the healing strength of antiangiogenic brokers together with the opposite cures within the armamentarium to struggle melanoma can be an on-going problem. Antiangiogenic brokers in melanoma remedy, moment variation presents a present, up-dated standpoint at the state-of-the-art of angiogenesis and remedy with a compendium of clinical findings and methods to the examine of angiogenesis in melanoma. Leaders within the box current chapters on such themes because the environmental affects and the genetic and physiologic abnormalities that mediate angiogenesis and its position within the development of malignant illness, operating versions of tumor angiogenesis, and the function of angiogenesis inhibition within the treatment of malignant ailment in people. entire and state of the art, Antiangiogenic brokers in melanoma remedy, moment version is a perfect, necessary advisor to the newest advances within the box, and a suite that might be precious for a few years to come back.

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42. Hotz HG, Hines OJ, Masood R, et al. VEGF antisense therapy inhibits tumor growth and improves survival in experimental pancreatic cancer. Surgery 2005;137:192–199. 43. Paavonen K, Horelli-Kuitunen N, Chilov D, et al. Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively. Circulation 1996;93:1079–1082. Chapter 1 / VEGF Family and Its Receptors 19 44. Bellomo D, Headrick JP, Silins GU, et al. Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia.

Clin Cancer Res 2006;12:2197–2207. 152. Smith LE, Shen W, Perruzzi C, et al. Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor. Nat Med 1999;5:1390–1395. 153. Miele C, Rochford JJ, Filippa N, Giorgetti-Peraldi S, Van Obberghen E. Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways. J Biol Chem 2000;275:21695–21702. 154. Reinmuth N, Fan F, Liu W, et al.

J Cell Sci 1998;111: 1853–1865. 191. Fukumura D, Gohongi T, Kadambi A, Izumi Y, Ang J, Yun CO, Buerk DG, Huang PL, Jain RK. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci USA 2001;98:2604–2609. 192. Eliceiri BP, Paul R, Schwartzberg PL, Hood JD, Leng J, Cheresh DA. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell 1999;4:915–924.

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Antiangiogenic Agents in Cancer Therapy, Second Edition (Cancer Drug Discovery and Development) by Beverly A. Teicher


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