By Thomas F. Kresina
An advent to Molecular drugs and Gene remedy Edited by way of Thomas F. Kresina, Ph.D. Gene treatment, or using genetic manipulation for ailment remedy, is derived from advances in genetics, molecular biology, medical medication, and human genomics. Molecular drugs, the applying of molecular organic options to sickness therapy and analysis, is derived from the advance of human organ transplantation, pharmacotherapy, and elucidation of the human genome. An advent to Molecular medication and Gene remedy presents a foundation for reading new scientific and uncomplicated study findings within the parts of cloning, gene move, and focusing on; the functions of genetic drugs to scientific stipulations; ethics and governmental laws; and the burgeoning fields of genomics, biotechnology, and bioinformatics. by way of dividing the cloth into 3 sections - an creation to uncomplicated technological know-how, a evaluation of medical functions, and a dialogue of the evolving matters relating to gene remedy and molecular medicine-this entire handbook describes the elemental ways to the wide diversity of exact and capability genetic-based cures. additionally, An creation to Molecular drugs and Gene remedy: * Covers new frontiers in gene remedy, animal versions, vectors, gene focusing on, and ethical/legal issues * presents organ-based stories of present experiences in gene treatment for monogenetic, multifactoral or polygenic problems, and infectious illnesses * comprises bold-faced phrases, key strategies, summaries, and lists of important references through topic in every one bankruptcy * comprises appendices on advertisement implications and a evaluation of the background of gene remedy This textbook bargains a transparent, concise writing type, drawing upon the services of the authors, all popular researchers of their respective specialties of molecular medication. Researchers in genetics and molecular medication will all locate An advent to Molecular medication and Gene remedy to be a necessary advisor to the quickly evolving box of gene treatment and its functions in molecular medication.
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Extra resources for An Introduction to Molecular Medicine and Gene Therapy
2 Schematic representation of a system in which genotype and phenotype are related by a complex network of interactions involving many proteins, RNAs, and reactants. Drug binding to a specific component leads to complex effects, lowering levels of some biosynthetic products, raising levels of others. Through a series of feedback loops, expression of some genes is up-regulated and of other genes down-regulated. ) 8 MOLECULAR MEDICINE AND GENE THERAPY: AN INTRODUCTION gene and the down-regulation of another.
Benefits (see Chapter 14). The targets of many current phase I therapies are genetic lesions causing disease in children and young adults. Successful gene therapy in these cases will save lives but not necessarily increase life expectancy or longevity. If gene therapies are to produce major increases in longevity, they will have to target diseases of the elderly, but which diseases? The holy grail of gene therapy would be to identify a transgene that modifies the biological clock and the aging process.
Be social, live longer. Nature 389:906–907, 1997. Jazwinski SM. Longevity, genes, and aging. Science 273:54–59, 1996.
An Introduction to Molecular Medicine and Gene Therapy by Thomas F. Kresina