By Charles A. Schiffer (auth.), Anjali S. Advani, Hillard M. Lazarus (eds.)
The present explosion of recent components of controversy within the remedy of acute lymphocytic leukemia in adults and teenagers makes this complete e-book a miles wanted reference for hematologists and oncologists. This ebook assembles best specialists from world wide to hide the complete spectrum of ALL subtypes and their remedies. particular issues of debate contain symptoms for allogeneic bone marrow transplant in first entire remission, the function of minimum residual ailment in making remedy judgements, the therapy of teenagers, and the remedy of Philadelphia chromosome confident ALL with the appearance of the tyrosine kinase inhibitors. this is often the 1st ebook to concentration solely at the grownup ALL sufferer. It presents an entire assessment of analysis, molecular pathogenesis, assessment, and therapy for this significant sufferer population.
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Additional resources for Adult Acute Lymphocytic Leukemia: Biology and Treatment
1998). Deregulated expression of the TAL1 gene by t(1;5)(p32;31) in patient with T-cell acute lymphoblastic leukemia. Genes, Chromosomes & Cancer, 23(1), 36–43. 52. , et al. (2002). A single split-signal FISH probe set allows detection of TAL1 translocations as well as SIL-TAL1 fusion genes in a single test. Leukemia, 16(4), 755–761. 53. Curry, J. , & Smith, M. T. (2003). Measurement of SIL-TAL1 fusion gene transcripts associated with human T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR.
Conceptually, and in murine models, leukemia may evolve from a gain of function, depending on the partner gene involved, or a disruption of normal MLL function. The most common translocation is the t(4;11), which fuses MLL to AF4. ALL with t(4;11) has a dismal prognosis in both infants and adults . Gene expression studies have demonstrated that MLL is transcriptionally distinct compared to AML and ALL . Since MLL gene shares significant homology to the drosophila Homeobox (Hox) control gene Trithorax (Trx), it is not surprising that MLL shows dysregulation of several HOX genes, particularly HOXA9 and HOXA5.
However, genes involved in apoptosis and cell proliferation are clearly underexpressed in leukemia resistant to chemotherapy [89, 94, 97, 98]. There have been relatively few studies examining global gene expression in adult ALL [91, 99, 100], likely due to the rarity of the disease in older patients and the lower enrollment in clinical trials. However, findings in pediatric leukemia are likely relevant to adults, as shown by the validation of pediatric gene expression signatures for different leukemia subtypes in an independent adult cohort .
Adult Acute Lymphocytic Leukemia: Biology and Treatment by Charles A. Schiffer (auth.), Anjali S. Advani, Hillard M. Lazarus (eds.)